RESEARCH HIGHLIGHTS
Optical coherence multiplexing in the second near infrared window
I invented first-in-class contrast nanoprobes that enable OCT to visualize multiple biological processes simultaneously in the second near-infrared window, which allows light to penetrate much deeper in tissue compared to other imaging windows.
Contrast-enhanced tumor microvascular imaging
I developed a nanoparticle contrast agent which significantly enhances the sensitivity of OCT for microvasculature imaging and allows OCT to detect the finest tumor blood vessels which can be otherwise overlooked by label-free OCT methods.
Optical coherence molecular imaging
I developed an OCT molecular imaging strategy which allows visualizing the dynamic expression of an inflammation biomarker—lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) for the first time in the tissue of a living subject.