Peng Si, PhD

Optical coherence multiplexing in the second near infrared window

I invented first-in-class contrast nanoprobes that enable OCT to visualize multiple biological processes simultaneously in the second near-infrared window, which allows light to penetrate much deeper in tissue compared to other imaging windows. 

Contrast-enhanced tumor microvascular imaging

I developed a nanoparticle contrast agent which significantly enhances the sensitivity of OCT for microvasculature imaging and allows OCT to detect the finest tumor blood vessels which can be otherwise overlooked by label-free OCT methods. 

Optical coherence molecular imaging

I developed an OCT molecular imaging strategy which allows visualizing the dynamic expression of an inflammation biomarker—lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) for the first time in the tissue of a living subject.